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Thailand Honors Human Genome Project Team at NIH

By Larry Luxner

It’s not every day a Southeast Asian monarchy bestows a $100,000 prize on a U.S. government research agency. In fact, it doesn’t even happen every year.

But this year is different. Thailand’s Prince Mahidol Award Foundation has chosen the National Human Genome Research Institute — a division of the National Institutes of Health (NIH) — to receive its 2017 Prince Mahidol Award for groundbreaking advances in the field of medicine.

Specifically, the award recognizes the institute for leading NIH’s work on the Human Genome Project. Its director, Dr. Eric Green, received the award Jan. 31 during an elaborate royal ceremony at Bangkok’s Grand Palace presided over by Princess Maha Chakri Sirindhorn.


Ambassador Virachai Plasai delivering his opening remarks. (Photo: Larry Luxner)

On April 23, he and four recipients of a separate award in the field of public health were honored at a dinner hosted by the Royal Thai Embassy in Washington.

“The Human Genome Project, launched in 1990, was one of the largest research projects in genetics,” said Virachai Plasai, Thailand’s new ambassador to the United States, speaking on his first day on the job to about 50 invited dinner guests at the St. Regis Hotel. “Its mission was to decipher human genetic codes and contribute to a better understanding of cellular and organ functions, mutation processes and mechanisms of diseases — from rare hereditary diseases to common illnesses.”

Some 80 percent of the 7,000 or so known rare diseases are genetic in origin, and about half of those affected are children — yet 95 percent of such disease don’t have a single treatment approved by the U.S. Food and Drug Administration. Rare diseases cause more than a third of all deaths in the first year of life, and an estimated 30 percent of kids with a rare disease will not live to see their fifth birthday.


Dr. Rachel Schneerson, one of 2017 Prince Mahidol Laureates in the field of public health, sharing her views on the advancement of medical sciences. (Photo: Larry Luxner)

“Information provided by the Human Genome Project has helped make significant progress in medical science,” said Plasai. “In particular, it has changed the medical paradigm of the investigation of causes and related genetic risks of diseases.”

Since its establishment in 1992 to honor Prince Mahidol of Songkla — considered the father of modern medicine and public health in Thailand — the royal family has given the award to 78 individuals and two institutions in 23 countries. This year, however, all five laureates represent the United States.

Green, speaking for his colleagues, was a “start-to-finish” researcher on the Human Genome Project before becoming director of the National Genome Research Institute in 2009.

“This was an international effort that took place from 1990 to 2003, involving thousands of scientists from around the world — to decode the human blueprint of DNA and make that information available to scientists everywhere,” he said. “That effort, which involved multiple countries, completed its endeavor 15 years ago. It is changing the way we practice medicine, and the fact it’s doing so only 15 years later is incredible.”


Chotika Kerdsommas performing Khan Dok dance. (Photo: Larry Luxner)

He said that the resulting human genome sequence “has provided a foundation on which researchers and clinicians now tackle increasingly complex problems,” transforming the study of human biology and disease.

“Particularly gratifying has been the ability to begin using genomics to improve approaches for diagnosing and treating human disease, ushering in the era of genomic medicine,” said Green.

In addition to Green and his team, the 2017 winners in the field of public health are five scientists who improved the vaccine for Haemophilus influenzae type b — also known as Hib — which is the leading cause of bacterial meningitis among Americans under the age of 5.

The laureates are Dr. Rachel Schneerson and Dr. John Robbins, who headed a research team when both worked at the Eunice Kennedy Shriver National Institute of Child Health and Human Development; Dr. Porter Anderson of Harvard University and New York’s University of Rochester; and Dr. Mathuram Santosham of Baltimore’s Johns Hopkins University.

“It is gratifying, of course, to have our work recognized, and the contributions of our many colleagues — both in and out of the lab — that we were lucky to have over the years should be acknowledged,” said the Polish-born Schneerson, 85, who graduated from Israel’s Hebrew University Hadassah Medical School in 1958, spent most of her career in the United States and retired in 2012.

She added: “The importance of this award is in highlighting health and scientific problems facing us, showing us what was and what can be done, and encouraging young people to further this work and prevent infectious diseases for the benefit of all.”

 


Larry Luxner is the news editor at The Washington Diplomat.

 
 

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